Julia Garth, a female doctor, plans to introduce modern techniques of medicine to old Santa Fe in 1880, but is opposed by an established doctor, Rourke O’Brien.

Duncan MacDonald, a 19th-century Royal Canadian Mountie, has to escort a group of Cree Indians back to their above-the-border reservation. His guide in this endeavor is the not-too-trustworthy half-breed Natayo.